FilmArray® Panels

Comprehensive Panels and Better Diagnostics

Comprehensive panels take out the guess work, giving laboratories and healthcare providers a higher probability of identifying pathogens associated with infectious disease. Designed with the syndromic approach in mind, each panel combines a broad grouping of probable pathogenic causes into a single, rapid test.

 

The five, FDA-cleared FilmArray panels test for viruses, bacteria, parasites, yeast and antimicrobial resistance genes. Whether you’re trying to select appropriate therapy for a septic patient or determine exactly which respiratory pathogen is making a young child sick, the FilmArray® System can return answers fast. Click on the icons to learn more.

Respiratory Panel

Sample Type: Nasopharyngeal swab

20 TARGETS IN ONE TEST

The FilmArray® Respiratory Panel (RP) tests for a comprehensive set of 20 respiratory viral and bacterial pathogens in about an hour. The Respiratory Panel identifies the most common viral and bacterial pathogens that cause respiratory tract infections that present with nearly indistinguishable symptoms. The rapid and accurate identification of the causative agent helps determine how a healthcare provider chooses to treat an upper respiratory tract infection.

RESPIRATORY PANEL MENU

VIRUSES:

  • Adenovirus
  • Coronavirus HKU1
  • Coronavirus NL63
  • Coronavirus 229E
  • Coronavirus OC43
  • Human Metapneumovirus
  • Human Rhinovirus/Enterovirus
  • Influenza A
  • Influenza A/H1
  • Influenza A/H3
  • Influenza A/H1-2009
  • Influenza B
  • Parainfluenza Virus 1
  • Parainfluenza Virus 2
  • Parainfluenza Virus 3
  • Parainfluenza Virus 4
  • Respiratory Syncytial Virus

BACTERIA:

  • Bordetella pertussis
  • Chlamydophila pneumoniae
  • Mycoplasma pneumoniae

Featured RP Research Paper

Point-Counterpoint: Large multiplex PCR panels should be first line tests for detection of respiratory and intestinal pathogens

Schreckenberger P, McAdam A

The first FDA-approved multiplex PCR panel for a large number of respiratory pathogens was introduced in 2008. Since then, other PCR panels for detection of several respiratory and gastrointestinal pathogens have been approved by the FDA and are commercially available, and more such panels are likely to become available. In this Point-Counterpoint, Dr. Paul Schreckenberger of Loyola University Medical Center explains why his laboratory offers these assays without restriction. Dr. Alex McAdam of Boston’s Children Hospital explains the concerns about the use of these assays as first-line tests and why some limitations on their use might be appropriate.

Respiratory Panel EZ

Sample Type: Nasopharyngeal swab

14 TARGETS IN ONE TEST

The FilmArray® Respiratory Panel (RP) EZ tests for a comprehensive set of 14 respiratory viral and bacterial pathogens in about an hour. RP EZ is a CLIA-waived version of the CE-IVD, FDA-cleared Respiratory Panel (RP), and is designed to run on a single computer/instrument configuration (EZ Configuration) of the FilmArray 2.0 System.

Product not available outside U.S.

RESPIRATORY PANEL EZ MENU

VIRUSES:

  • Adenovirus
  • Coronavirus
  • Human Metapneumovirus
  • Human Rhinovirus/Enterovirus
  • Influenza A
  • Influenza A/H1
  • Influenza A/H3
  • Influenza A/H1-2009
  • Influenza B
  • Parainfluenza Virus
  • Respiratory Syncytial Virus

BACTERIA:

  • Bordetella pertussis
  • Chlamydophila pneumoniae
  • Mycoplasma pneumoniae

Respiratory Panel 2 (RP2)

Sample Type: Nasopharyngeal swab

21 TARGETS IN ONE TEST

The FilmArray® Respiratory Panel 2 (RP2) is now faster, more accurate, and more comprehensive than ever. An unprecedented run time of about 45 minutes enables higher efficiency and throughput on the FilmArray® 2.0 and the FilmArray® Torch Systems and offers potentially faster results to clinicians enabling better informed diagnosis and treatment of patients. Higher overall sensitivity across a broader spectrum of pathogens means that the FilmArray RP2 offers the world the fastest way to better results in the detection of respiratory infections.

RESPIRATORY PANEL 2 MENU

VIRUSES:

  • Adenovirus
  • Coronavirus HKU1
  • Coronavirus NL63
  • Coronavirus 229E
  • Coronavirus OC43
  • Human Metapneumovirus
  • Human Rhinovirus/Enterovirus
  • Influenza A
  • Influenza A/H1
  • Influenza A/H3
  • Influenza A/H1-2009
  • Influenza B
  • Parainfluenza Virus 1
  • Parainfluenza Virus 2
  • Parainfluenza Virus 3
  • Parainfluenza Virus 4
  • Respiratory Syncytial Virus

BACTERIA:

  • Bordetella pertussis
  • Bordetella parapertussis
  • Chlamydia pneumoniae
  • Mycoplasma pneumoniae

Blood Culture Identification Panel

Sample Type: Positive Blood Culture

27 TARGETS IN ONE TEST

The FilmArray® Blood Culture Identification (BCID) Panel tests for a comprehensive set of 24 gram positive, gram negative and yeast pathogens and 3 antibiotic resistance genes associated with bloodstream infections. The BCID Panel detects and identifies the most common causes of bloodstream infections. Quickly identifying the cause of sepsis may help clinicians more rapidly and appropriately manage septic patient therapy. Rapid identification of bloodstream pathogens may help reduce the time to appropriate antimicrobial therapy and positively impact patient survival.

BCID PANEL MENU

GRAM-POSITIVE BACTERIA:

  • Enterococcus
  • Listeria monocytogenes
  • Staphylococcus
  • Staphylococcus aureus
  • Streptococcus
  • Streptococcus agalactiae
  • Streptococcus pneumoniae
  • Streptococcus pyogenes

GRAM-NEGATIVE BACTERIA:

  • Acinetobacter baumannii
  • Haemophilus influenzae
  • Neisseria meningitidis
  • Pseudomonas aeruginosa
  • Enterobacteriaceae
  • Enterobacter cloacae complex
  • Escherichia coli
  • Klebsiella oxytoca
  • Klebsiella pneumoniae
  • Proteus
  • Serratia marcescens

YEAST:

  • Candida albicans
  • Candida glabrata
  • Candida krusei
  • Candida parapsilosis
  • Candida tropicalis

ANTIMICROBIAL RESISTANCE GENES:

  • mecA – methicillin resistance
  • vanA/B – vancomycin resistance
  • KPC – carbapenem resistance

Featured BCID Research Paper

Unanticipated multiplex PCR identification of polymicrobial blood culture resulting in earlier isolation, susceptibilities, and optimization of clinical care

Timbrook T, Boger MS, Steed LL, Hurst JM

A case of polymicrobial bloodstream infection that was initially thought to be a monomicrobial infection is described in which six organisms were identified using multiplex PCR. Early recognition of specific gram-positive, gram-negative, and fungal organisms and resistance elements allowed for significantly more rapid optimization of therapy.

Gastrointestinal Panel

Sample Type: Stool in Cary Blair

22 TARGETS IN ONE TEST

The FilmArray® Gastrointestinal (GI) Panel tests for a comprehensive set of 22 gastrointestinal pathogens. The FilmArray GI Panel tests stool specimens for common pathogens associated with gastroenteritis. Quickly identifying the correct pathogen can ensure appropriate treatment, patient management and help decrease infectious gastroenteritis which can lead to severe illness or death.

GI PANEL MENU

BACTERIA:

  • Campylobacter (jejuni, coli and upsaliensis)
  • Clostridium difficile (toxin A/B)
  • Plesiomonas shigelloides
  • Salmonella
  • Yersinia enterocolitica
  • Vibrio (parahaemolyticus, vulnificus and cholerae)
  • Vibrio cholerae

DIARRHEAGENIC E. COLI/SHIGELLA:

  • Enteroaggregative E. coli (EAEC)
  • Enteropathogenic E. coli (EPEC)
  • Enterotoxigenic E. coli (ETEC) lt/st
  • Shiga-like toxin-producing E. coli (STEC) stx1/stx2
  • E. coli O157
  • Shigella/Enteroinvasive E. coli (EIEC)

PARASITES:

  • Cryptosporidium
  • Cyclospora cayetanensis
  • Entamoeba histolytica
  • Giardia lamblia

 

VIRUSES:

  • Adenovirus F40/41
  • Astrovirus
  • Norovirus GI/GII
  • Rotavirus A
  • Sapovirus (I, II, IV & V)

Featured GI Research Paper

Multicenter evaluation of the BioFire FilmArray gastrointestinal panel for etiologic diagnosis of infectious gastroenteritis

Buss S, Leber A, Chapin K, Fey P, Bankowski M, Jones M, Rogatcheva M, Kanack K, Bourzac K

The appropriate treatment and control of infectious gastroenteritis depend on the ability to rapidly detect the wide range of etiologic agents associated with the disease. Clinical laboratories currently utilize an array of different methodologies to test for bacterial, parasitic, and viral causes of gastroenteritis, a strategy that suffers from poor sensitivity, potentially long turnaround times, and complicated ordering practices and workflows. This study assessed the performance of the FilmArray Gastrointestinal (GI) Panel for the simultaneous detection of 22 different enteric pathogens directly from stool specimens.

Meningitis Encephalitis Panel

Sample Type: Cerebrospinal Fluid (CSF)

14 TARGETS IN ONE TEST

The FilmArray® Meningitis/Encephalitis (ME) Panel tests for a comprehensive set of 14 bacteria, viruses and yeast. The FilmArray ME Panel identifies the most common viral, bacterial and yeast pathogens that cause infections in the central nervous system which in some cases can be life-threatening. The diagnosis of meningitis and encephalitis can allow faster decisions on appropriate therapy to be made to prevent complications.

ME PANEL MENU

BACTERIA:

  • Escherichia coli K1
  • Haemophilus influenzae
  • Listeria monocytogenes
  • Neisseria meningitidis
  • Streptococcus agalactiae
  • Streptococcus pneumoniae

VIRUSES:

  • Cytomegalovirus (CMV)
  • Enterovirus
  • Herpes simplex virus 1 (HSV-1)
  • Herpes simplex virus 2 (HSV-2)
  • Human herpesvirus 6 (HHV-6)
  • Human parechovirus
  • Varicella zoster virus (VZV)

YEAST:

  • Cryptococcus neoformans/gattii

Featured ME Research Paper

Diagnostic performance of a multiplex PCR assay for meningitis in an HIV-infected population in Uganda

Rhein J, Bahr NC, Hemmert AC, Cloud JL, Bellamkonda S, Oswald C, Lo E, Nabeta H, Kiggundu R, Akampurira A, Musubire A, Williams DA, Meya DB, Boulware DR; ASTRO-CM Team

Meningitis remains a worldwide problem, and rapid diagnosis is essential to optimize survival. We evaluated the utility of a multiplex PCR test in differentiating possible etiologies of meningitis. Cerebrospinal fluid (CSF) from 69 HIV-infected Ugandan adults with meningitis was collected at diagnosis (n=51) and among persons with cryptococcal meningitis during therapeutic lumbar punctures (n=68). Cryopreserved CSF specimens were analyzed with BioFire FilmArray® Meningitis/Encephalitis panel (IUO version), which targets 17 pathogens. The panel detected Cryptococcus in the CSF of patients diagnosed with a first episode of cryptococcal meningitis by fungal culture with 100% sensitivity and specificity and differentiated between fungal relapse and paradoxical immune reconstitution inflammatory syndrome in recurrent episodes. A negative FilmArray result was predictive of CSF sterility on follow-up lumbar punctures for cryptococcal meningitis. EBV was frequently detected in this immunosuppressed population (n=45). Other pathogens detected included: cytomegalovirus (n=2), varicella zoster virus (n=2), human herpes virus 6 (n=1), and Streptococcus pneumoniae (n=1). The FilmArray Meningitis/Encephalitis panel offers a promising platform for rapid meningitis diagnosis.