Comprehensive panels take out the guess work, giving laboratories and healthcare providers a higher probability of identifying pathogens associated with infectious disease. Designed with the syndromic approach in mind, each panel combines a broad grouping of probable pathogenic causes into a single, rapid test.
The five, FDA-cleared FilmArray panels test for viruses, bacteria, parasites, yeast and antimicrobial resistance genes. Whether you’re trying to select appropriate therapy for a septic patient or determine exactly which respiratory pathogen is making a young child sick, the FilmArray® System can return answers fast. Click on the icons to learn more.
Sample Type: Nasopharyngeal swab
The FilmArray® Respiratory Panel (RP) tests for a comprehensive set of 20 respiratory viral and bacterial pathogens in about an hour. The Respiratory Panel identifies the most common viral and bacterial pathogens that cause respiratory tract infections that present with nearly indistinguishable symptoms. The rapid and accurate identification of the causative agent helps determine how a healthcare provider chooses to treat an upper respiratory tract infection.
Point-Counterpoint: Large multiplex PCR panels should be first line tests for detection of respiratory and intestinal pathogens
Schreckenberger P, McAdam A
The first FDA-approved multiplex PCR panel for a large number of respiratory pathogens was introduced in 2008. Since then, other PCR panels for detection of several respiratory and gastrointestinal pathogens have been approved by the FDA and are commercially available, and more such panels are likely to become available. In this Point-Counterpoint, Dr. Paul Schreckenberger of Loyola University Medical Center explains why his laboratory offers these assays without restriction. Dr. Alex McAdam of Boston’s Children Hospital explains the concerns about the use of these assays as first-line tests and why some limitations on their use might be appropriate.
Sample Type: Nasopharyngeal swab
The FilmArray® Respiratory Panel (RP) EZ tests for a comprehensive set of 14 respiratory viral and bacterial pathogens in about an hour. RP EZ is a CLIA-waived version of the CE-IVD, FDA-cleared Respiratory Panel (RP), and is designed to run on a single computer/instrument configuration (EZ Configuration) of the FilmArray 2.0 System.
Product not available outside U.S.
Sample Type: Positive Blood Culture
The FilmArray® Blood Culture Identification (BCID) Panel tests for a comprehensive set of 24 gram positive, gram negative and yeast pathogens and 3 antibiotic resistance genes associated with bloodstream infections. The BCID Panel detects and identifies the most common causes of bloodstream infections. Quickly identifying the cause of sepsis may help clinicians more rapidly and appropriately manage septic patient therapy. Rapid identification of bloodstream pathogens may help reduce the time to appropriate antimicrobial therapy and positively impact patient survival.
ANTIMICROBIAL RESISTANCE GENES:
Unanticipated multiplex PCR identification of polymicrobial blood culture resulting in earlier isolation, susceptibilities, and optimization of clinical care
Timbrook T, Boger MS, Steed LL, Hurst JM
A case of polymicrobial bloodstream infection that was initially thought to be a monomicrobial infection is described in which six organisms were identified using multiplex PCR. Early recognition of specific gram-positive, gram-negative, and fungal organisms and resistance elements allowed for significantly more rapid optimization of therapy.
Sample Type: Stool in Cary Blair
The FilmArray® Gastrointestinal (GI) Panel tests for a comprehensive set of 22 gastrointestinal pathogens. The FilmArray GI Panel tests stool specimens for common pathogens associated with gastroenteritis. Quickly identifying the correct pathogen can ensure appropriate treatment, patient management and help decrease infectious gastroenteritis which can lead to severe illness or death.
DIARRHEAGENIC E. COLI/SHIGELLA:
Multicenter evaluation of the BioFire FilmArray gastrointestinal panel for etiologic diagnosis of infectious gastroenteritis
Buss S, Leber A, Chapin K, Fey P, Bankowski M, Jones M, Rogatcheva M, Kanack K, Bourzac K
The appropriate treatment and control of infectious gastroenteritis depend on the ability to rapidly detect the wide range of etiologic agents associated with the disease. Clinical laboratories currently utilize an array of different methodologies to test for bacterial, parasitic, and viral causes of gastroenteritis, a strategy that suffers from poor sensitivity, potentially long turnaround times, and complicated ordering practices and workflows. This study assessed the performance of the FilmArray Gastrointestinal (GI) Panel for the simultaneous detection of 22 different enteric pathogens directly from stool specimens.
Sample Type: Cerebrospinal Fluid (CSF)
The FilmArray® Meningitis/Encephalitis (ME) Panel tests for a comprehensive set of 14 bacteria, viruses and yeast. The FilmArray ME Panel identifies the most common viral, bacterial and yeast pathogens that cause infections in the central nervous system which in some cases can be life-threatening. The diagnosis of meningitis and encephalitis can allow faster decisions on appropriate therapy to be made to prevent complications.
Diagnostic performance of a multiplex PCR assay for meningitis in an HIV-infected population in Uganda
Rhein J, Bahr NC, Hemmert AC, Cloud JL, Bellamkonda S, Oswald C, Lo E, Nabeta H, Kiggundu R, Akampurira A, Musubire A, Williams DA, Meya DB, Boulware DR; ASTRO-CM Team
Meningitis remains a worldwide problem, and rapid diagnosis is essential to optimize survival. We evaluated the utility of a multiplex PCR test in differentiating possible etiologies of meningitis. Cerebrospinal fluid (CSF) from 69 HIV-infected Ugandan adults with meningitis was collected at diagnosis (n=51) and among persons with cryptococcal meningitis during therapeutic lumbar punctures (n=68). Cryopreserved CSF specimens were analyzed with BioFire FilmArray® Meningitis/Encephalitis panel (IUO version), which targets 17 pathogens. The panel detected Cryptococcus in the CSF of patients diagnosed with a first episode of cryptococcal meningitis by fungal culture with 100% sensitivity and specificity and differentiated between fungal relapse and paradoxical immune reconstitution inflammatory syndrome in recurrent episodes. A negative FilmArray result was predictive of CSF sterility on follow-up lumbar punctures for cryptococcal meningitis. EBV was frequently detected in this immunosuppressed population (n=45). Other pathogens detected included: cytomegalovirus (n=2), varicella zoster virus (n=2), human herpes virus 6 (n=1), and Streptococcus pneumoniae (n=1). The FilmArray Meningitis/Encephalitis panel offers a promising platform for rapid meningitis diagnosis.